54P Efficacy of total neoadjuvant therapy (TNT) in rectal cancer: A meta-analysis of randomized controlled trials

Abstract

Surgery is performed after neoadjuvant chemoradiotherapy (CRT) as standard in locally advanced rectal cancer. However, in recent years, it has been observed that oncological outcomes can be improved with a treatment approach called total neoadjuvant therapy (TNT), applied with different strategies. This meta-analysis investigated the efficacy of randomized controlled trials (RCTs) comparing standard CRT with TNT.