546 Tissue Doppler imaging: a non-invasive technique for estimation of NT pro-BNP levels in patients with left ventricular dysfunction

Abstract

Purpose: While structural and functional abnormalities are known to occur among persons with diabetes and hypertension, the prevalence of these abnormalities in persons with metabolic syndrome (MS) but without diabetes or hypertension is unknown. The goal of this study is to estimate the prevalence of abnormal cardiac structure and function in community-dwelling men and women with MS. Methods: A population-based random sample of 2042 Olmsted County, MN residents, aged ≥ 45 years in 1997, was identified through the Rochester Epidemiology project (participation rate = 50%). Subjects with diabetes and hypertension were excluded. MS was defined by National Cholesterol Education Program Adult Treatment Panel III criteria. 2D, M-mode and Tissue Doppler Echocardiography were performed to assess cardiac structure and function. Results: Of the 1368 subjects, the prevalence of isolated MS was 33.1% in men and 24.6% in women. Among those with MS, women were older than men (mean± SD age 64.2±10.4 vs 59.4±9.3, p<0.001). The prevalence of left ventricular systolic dysfunction, left atrial volume index, left and right ventricular enlargement and presence of regional wall motion abnormalities was similar in subjects with and without MS. Left ventricular mass index was greater in women with MS than those without, but there was no difference in men. Similarly, diastolic dysfunction was more prevalent in women with MS (p<0.001), with age adjusted odds ratio of 1.82 (95% CI 1.13, 2.93; p=0.01), whereas in men this difference was not observed.