Abstract
The actual trend to use chemotherapy in the neoadjuvant setting, with high rates of pathologic complete responses, raises questions about de-escalation of locoregional treatment. Sentinel lymph node biopsy (SLNB) in biopsy-proven node positive patients (cN1) who have a clinical complete response after neoadjuvant chemotherapy (NAC) is still controversial. Trying to minimize false negative results of SLNB procedure some groups have been using different markers (metallic clips, guide wires, iodine seeds, etc) to tag positive lymph nodes before NAC and facilitate their retrieval during surgery. The objective of this feasibility study was to test the use of carbon dye as a marker and the role of double marking with a clip to improve accuracy of axillary staging with SLNB.
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