Abstract
Background: New promoters for high level short-term glia-specific expression have been created. These 'super' promoters are based on the promoter of the gene for glial fibrillary acidic protein (GFAP). Addition of three extra copies of the glia-specific enhancer elements A, B and D to the glia-specific 2.2 kb GFAP-promoter fragment (gfa2) resulted in 2 log higher expression levels after plasmid transfections. We describe the characteristics of these promoters in the context of the Ad5 E1 region in vitro and in vivo.
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