54 Discordance Between Pulmonary Embolism Risk Stratification and Elevated Lactate

Abstract

Identifying pulmonary embolism (PE) patients who are at high risk for mortality or decompensation is the goal of risk stratification in PE. While not commonly included in current risk stratification schemes, elevated lactate levels may be an early marker of hemodynamic collapse. Prior studies have shown elevated lactate is associated with adverse outcomes in PE, including 2.5x higher 30-day all-cause mortality. To further characterize the relationship between elevated lactate and PE risk stratification, this study evaluated the prevalence of elevated lactate by PE risk level in patients undergoing mechanical thrombectomy in the FlowTriever All-Comer Registry for Patient Safety and Hemodynamics (FLASH) and assessed acute hemodynamic improvements and safety outcomes through 30 days.