Abstract
539 - The circadian rhythm of bladder clock genes in spontaneously hypertensive rat
Highlights
Bladder clock genes in spontaneously hypertensive rat Circadian rhythms are under the control of clock gene products, which are present in most cells and organs of mammals
Body and bladder weights were significantly lower in the spontaneously hypertensive rats (SHR) group than in the control (Fig 1A and 1B), while 24-h voiding frequency in both the rest and active phases was significantly higher in the SHR group (Fig 1C)
The voided volume in the active phase was significantly higher than that in the rest phase for both groups, the 24-h urine volume in the active phase was significantly lower in the SHR group compared to the control group (Fig 1D)
Summary
Circadian rhythms are under the control of clock gene products, which are present in most cells and organs of mammals. The suprachiasmatic nucleus of the brain works as a master pacemaker [1] and synchronizes peripheral clock gene rhythms that exist in multiple tissues of the whole body, such as the lungs, liver, kidneys, and bladder [2, 3]. The mechanisms of these synchronizing pathways are likely to involve both hormonal and neuronal mechanisms; other pathways are not completely understood. Clock gene products constitute a circadian mechanism based on a self-sustaining transcription-translation feedback loop [5] Rotation of this feedback loop takes about 24 h and forms rhythms in various biological processes in the body. Several groups have reported that lower urinary tract functions are regulated by clock genes [6, 7]
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