Abstract
The development of new vascular structures is a pre-requisite for melanoma growth and spread. Endovascular progenitor cells (EVPs), residing in vessel walls give rise to mature endothelial cells and contribute to a new blood vessel network formation in the tumour. Sox9 is a transcription factor that is playing an important role in stem cell self-renewal and quiescence and is highly upregulated in EVPs. In this study, we aimed to explore its role in tumour vascularisation and metastasis. An endothelial-specific knock out mouse model, Sox9fl/fl/Cdh5CreERt2/Rosa-YFP was utilised to delete Sox9 conditionally in the endothelium.
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