536 UVA1 harmful effects and benefit of an enlarged photoprotection covering the whole UV spectrum

Abstract

UVA1 rays (340–400 nm) representing at least 75% of solar UVs, generate cellular oxidative stress and are able to induce cutaneous damage and impairment of functions (immunity, development, inflammation, dermal matrix organization). Clinically, they contribute to hyperpigmentation, immunosuppression, carcinogenesis and photoaging. State of the art sunscreens can filter UV rays up to 370 nm, but lack absorption in the 370–400 nm range supporting the development of new UVA1 filters. The absorber Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (MCE), exhibiting a peak of absorption at 385 nm has recently been listed in the Annex VI of EU authorized UV filters for use in suncreens.