Abstract
Purpose: MHC class-II molecules play central roles in immuno-recognition and rejection. Previously, we could demonstrate that statins inhibit rejection in a rat model of lung transplantation, but it is not clear whether the disruption of lipid rafts and thereby the uploading of peptides or the inhibition of MHC class-II molecule synthesis itself is responsible for this effect. In order to elucidate the underlying mechanisms, we now used a congenic strain combination.
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