535 Maternal and neonatal outcomes among women with and without SARS-CoV-2 infection during pregnancy

Abstract

Objective: To examine maternal and neonatal outcomes in women with and without SARS-CoV-2 during pregnancy. Study Design: We conducted a multicenter retrospective cohort study of all pregnant women delivering at three hospitals in a large not-for-profit health care organization from March through July 2020. We compared outcomes between women with and without confirmed SARS-CoV-2 during pregnancy. Coarsened exact matching was performed to match women with and without SARS-CoV-2 using maternal age, body mass index, gestational age at delivery, parity and institution of delivery. The primary outcome was a composite of maternal complications including stillbirth, postpartum hemorrhage, intraamniotic infection, endometritis and ICU admission. Secondary outcomes of neonatal complications included Apgar score <7 at 5 minutes and low birth weight. Outcomes were examined by adjusted binomial logistic regression analysis incorporating matched weights. Result(s): Of 2,714 women who delivered at the three hospitals, a diagnosis of SARS-CoV-2 was made in 122 (4.5%) women during the pregnancy. After coarsened exact matching, the study cohort included 486 women, 91 (18.7%) with a diagnosis of SARS-CoV-2 during pregnancy and 395 (81.3%) without this diagnosis. Demographic data showed that more Hispanic women were diagnosed with SARS-CoV-2 infection compared to other races. Compared to uninfected women, women with SARS-CoV-2 infection had statistically significant higher odds of the composite maternal outcome (6.6% vs. 14.3%;aOR 2.35 [95% CI 1.16-4.78). No statistically significant differences were seen between the groups regarding neonatal outcomes. Conclusion(s): Hispanic women were more likely to be infected during pregnancy with SARS-CoV-2, illustrating the racial disparity that exists within virus infectivity. Our data illustrates increased maternal morbidity with SARS-CoV-2 infection, but no differences in neonatal outcomes. [Formula presented] [Formula presented]Copyright © 2020