534 Serotype Distribution of Invasive Pneumococcal Disease in Infants in the Comunidad Valenciana (5 Million Inhabitants), Spain, 2007-2010

Abstract

Background: Invasive pneumococcal disease (IPD) is a cause of high mortality and morbidity worldwide. The currently available vaccines for infants include 7, (PCV7) and 13 (PCV13) serotypes.Objectives: 1. To describe the serotype distribution of isolates of S. pneumoniae from IPD in infants (≤ 6 years of age) in the Comunidad Valenciana from January 2007 untill 16th of April 2010. 2. To determine the serotype coverage of the different pneumococcal vaccines. Materials and Methods: All strains of S. Pneumoniae causing IPD in infants in the Comunidad Valenciana, were collected from the 22 participating hospitals. Serotyping was performed by serum slide agglutination (Denka-Seiken, Tokyo, Japan).Results: 116 Strains were collected. The most prevalent serotypes in order of prevalence were: 1 (19,8%), 19A (15,5%), 7F (12,1%), and 14 (8,6%). The serotype coverage of the pneumococcal vaccine in children ≤ 6 years is 21,6 % by the PCV7 and 75,0 % by the PCV13.Conclusions: •The four most prevalent serotypes in infants, causing IPD in the Comunidad Valenciana during the study period were 1, 19A, 7F and 14. •Taking into account the high serotype coverage (75,0% by PCV13) in infants of the most recent vaccine, it might be recommended to include the PCV13 vaccine in childhood immunization programs. •To draw definite conclusions about including these vaccines in childhood immunization calendars, the results of safety and cost-effectiveness studies about the future vaccines should be taken into account. PS: Data used from the Surveillance Network of the Valencia Community (MIVA network). Public Health Department, Valencia, Spain