531: Imatinib-Mesylate in combination with RAD reduces significantly chronic rejection (CR) after orthotopic lung transplantation (LTX) in an experimental rat model

Abstract

recruited. Two underwent repeat catheterisation and NT-proBNP sampling after 1 and 2 years treatment respectively and this data is included. Fourteen patients had IPAH. The remainder had PAH associated with chronic thromboembolic disease (n 11), connective tissue disease (n 6), congenital heart disease (n 5), drugs (n 1) and sarcoid (n 1). Haemodynamic results showed RA pressure 11 6mmHg, PA pressure 52 15, PCWP 11 5, Cardiac Index (CI) 2.5 0.7 L/min and PVR index 18.3 8 Wood units. We found significant correlation between NTproBNP and RA pressure (r 0.52, p 0.001), CI (r -0.59, p 0.0001) and PVR index (r 0.4, p 0.01). Mean PA pressure did not correlate with NT pro-BNP. Conclusions: NT-proBNP correlates well with RA pressure, cardiac index and PVR index in a heterogenous group of patients with PAH. Serial measures of NT-proBNP may act as a noninvasive marker of haemodynamic function and may help guide treatment in this patient population.