Abstract
The aim of this study is to clarify the neurophysiological mechanism of cognitive impairments in migraine patients. We evaluated the relationships between event-related potentials (ERPs) and clinical parameters. Thirty-one migraine patients diagnosed by ICHD-II were submitted for this study. They were enrolled in headache-free periods. Clinical subtype (with/without aura), severity, duration, and preventative medicine use were evaluated as clinical parameters. We used 2 tones counting oddball paradigm to elicit P3 activities. EEG was recorded from 20 electrodes on the scalp according to international 10/20 system. We assessed the distribution of generator activity in the cortex by standardized low-resolution brain electromagnetic tomography (sLORETA). Regression analyzes of these clinical parameters and ERP source activities for the entire time frame was computed using sLORETA. sLORETA revealed a significant negative correlation in both attack frequency per a month and preventative medicine use in the cingulate gyrus and superior frontal gyrus 280 ms after the onset of target stimuli. Therefore, migraine patients might have impairment of cognitive function, such as executive dysfunction. The dysfunction is reflected by the attenuated activity of the frontal gyrus in sLORETA.
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