Abstract
Introduction: Necrotizing Enterocolitis (NEC) is a lethal surgical emergency affecting the gastrointestinal tract of the premature infant. It is characterized by an unchecked inflammatory response leading to the accumulation of toxic nitric oxide (NO) metabolites and epithelial injury. The early molecular signaling pathways that govern this exuberant inflammatory response remain unclear. We hypothesize that interleukin-1beta (Il-1β), a cytokine up regulated early in NEC, may be responsible for the upregulation of inducible NO synthase (iNOS), the enzyme responsible for excess NO production in the intestine.
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