Abstract
Control of cell surface nanoarchitectures has attracted attention as a process that can be used in both basic research and for therapeutic applications. This chapter summarizes new strategies for the surface modification of living cells with synthetic polymers and the biointerfacial aspects of such immobilized polymers. In particular, N-methacryloyl mannosamine was synthesized as an artificial precursor of sialic acid, placed in contact with human cells, and incubated. Confirmation of delivery of the methacryloyl groups to carbohydrates on cell surfaces was obtained using a thiol-ene reaction. Various thiol-terminated polymers were covalently immobilized and unnatural functions were introduced to cell surfaces while preserving cell viability.
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