Abstract
Non-functioning pituitary adenomas (NFPAs) account for nearly 35% of all pituitary tumours but since no hormonal hypersecretion has been observed, the diagnosis of NFPAs remains difficult. Although the NFPAs are considered benign, in a proportion of patients, tumour recurrence and invasion have been observed. So far, no biomarkers for NFPAs monitoring are available. Differentially expressed microRNAs (miRs) have been shown biomarker potential in many solid tumours. In the present study, miRs expression profiles were analysed in patients with invasive (with or without recurrence) and non-invasive NFPAs.
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