Abstract
Topaz-1 was the first phase-III study demonstrating efficacy for the PD-L1 inhibitor durvalumab (D) in combination with gemcitabine (Gem) and cisplatin (Cis), and the combination has the potential to become a new first-line standard of care in biliary tract cancers (BTCs). The aim of this proof-of-concept study was to evaluate the efficacy of tremelimumab (two dosing regimens) in combination with CTx+D.
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