Abstract
529 Correlation Between the Area of High-signal Intensity on SPIO-enhanced MR Imaging and the Pathologic Size of Sentinel Node Metastases in Breast Cancer Patients with Positive Sentinel Nodes
Highlights
We previously demonstrated that superparamagnetic iron oxide (SPIO)-enhanced Magnetic resonance (MR) imaging is promising for the detection of metastases in sentinel nodes localized by Computed tomography (CT)-lymphography in patients with breast cancer
We demonstrated that SPIO-enhanced MR imaging accurately stages the axilla and may avoid even sentinel node biopsy in patients with breast cancer
We investigated the correlation between the area of high-signal intensity on SPIOenhanced MR imaging and the pathologic size of sentinel node metastases in breast cancer patients with pathologically positive sentinel nodes for determining the predictive criteria of the size of nodal metastases
Summary
We previously demonstrated that superparamagnetic iron oxide (SPIO)-enhanced MR imaging is promising for the detection of metastases in sentinel nodes localized by CT-lymphography in patients with breast cancer. Sentinel node biopsy is emerging as an alternative to axillary lymph node dissection for patients with breast cancer with clinically negative nodes [1,2,3,4,5]. Harisinghani et al demonstrated a sensitivity of 100% with a specificity of 95.7% for nodal staging using USPIO-enhanced MR imaging in 80 patients with prostate cancer [9]. Rockall et al reported that the sensitivity for nodal staging using USPIO-enhanced MR imaging in 768 lymph nodes from 44 patients with endometrial or cervical cancer was 100%, significantly higher than the conventional method using size criteria, which has a sensitivity of 27% [10]. A recent meta-analysis demonstrated that USPIO-enhanced MR imaging is sensitive and specific, and superior to other modalities in the detection of nodal metastases for various malignancies [12]
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