Abstract
indirect effect of decreased cartilage damage on aberrant bone remodeling. Conclusions: The dual goals of translation research are to discover novel disease mechanisms and to transform this information into new therapeutics for human disorders. Here we present data that implicate cysteinyl leukotrienes in early OA progression. Therefore, targeting of this pathway could represent an important area to OA research and treatment. In addition, the apparent similarities of the DMM model to humans at risk for OA from meniscal damage, suggests that treatment proximal to the time of meniscal repair with CysLT antagonists could delay the structural progression of incipient OA. Subchondral bony sclerosis is a contributing co-factor in OA progression. Although, the reduction in cartilage damage observed in this study could be seen as the most clinically relevant outcome for montelukast treatment of OA, prevention of abnormal bone remodeling could have equally important outcomes in OA joint prophylaxis. 528
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