526 The involvement of gremlin 1 in particulate matter-induced melanogenesis

Abstract

Particulate matter (PM) is known as a major concern for human health because it is closely associated with mortality and morbidity from respiratory and cardio- and neurovascular diseases. Recently, it has been reported that PM can aggravate allergic skin diseases by affecting the skin barrier or inducing inflammation. Along with our previous reports that PM promotes melanin production via ER-mediated IRE1α signaling pathway, we also performed high-throughput single-cell RNA sequencing analysis using PM-delivered ex vivo human skin tissues to find out target molecules in different skin cell types, keratinocytes, melanocytes, fibroblasts, etc.