Abstract
Background: SN (sentinel node) biopsy is a common procedure in surgical treatment of clinically node-negative breast cancer patients. OSNA (One-step nucleic acid amplification) is a semi-automated examination using molecular biological technique and allows straightforward diagnosis of SN metastasis without a pathologist by quantitative evaluation of CK19 m-RNA as a copy number of OSNA. In this study, we compared OSNA analysis to histological investigation by pathologists for determining the suitability of OSNA, and we also examined that the copy number of OSNA is related with primary tumor characteristics or not.
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