Abstract
5214Restoring perivascular adipose tissue function in obesity using exercise
Highlights
Perivascular adipose tissue (PVAT) is a highly metabolically active tissue which surrounds the majority of blood vessels and contributes to the modulation of vascular tone [1,2,3]
We have indicated that PVAT function is mediated in part by β3-adrenoceptors [37]; in an attempt to rescue PVAT dysfunction in obesity, the effects of the β3-adrenoceptor agonist were tested
We have previously demonstrated that the PVAT anti-contractile effect in health is mediated by a combination of β3-adrenoceptormediated anti-contractile factor release, and NA uptake into adipocytes by organic cation transporter 3 (OCT3) [37]
Summary
Perivascular adipose tissue (PVAT) is a highly metabolically active tissue which surrounds the majority of blood vessels and contributes to the modulation of vascular tone [1,2,3]. We have presented evidence that the mechanisms of this effect are mediated via the sympathetic nervous system and are two-fold [4]; first, sympathetic nerve-derived noradrenaline (NA) activates adipocyte β3-adrenoceptors, which. PVAT function is lost, which may contribute to development of metabolic syndrome [5,6,7]. It is well known that in obesity, pathological over-activity of the sympathetic nervous system occurs [8, 9]. Cardiac βadrenoceptors become desensitised in heart failure, as a result of sympathetic nerve over-activity [10]. It is possible that in PVAT, increased sympathetic activity could result in a desensitisation of β3-adrenoceptors, leading to reduced adiponectin release. Bioavailability of adiponectin has already been demonstrated to be reduced in human obesity [11], hypertension [12], and type II diabetes [13]
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