Abstract
Introduction Both serotoninergic antidepressants and anticoagulants are widely udes in psychogeriatry. These drugs can develop drug interactions with subsequent risk of bleeding. Objectives, aims To determine risk of potential drug interactions between serotoninergic antidepressants and anticoagulants serotoninergic antidepressants and anticoagulants with subsequent risk of bleeding. Methods Retrospective analysis of medical records and laboratory checks (INR values) in senior patients treated with serotoninergic antidepressants and anticoagulants (Mental hospital Kromeriz, Czech republic, year 2011). Results In 15.5% of patients treated with combination serotoninergic antidepressant / anticoagulant the dosage of anticoagulant had to be decreased due to unwanted elevation of INR value. In 0.6% of patients the risk of bleeding was clinically evident. Conclusion Serotoninergic antidepressants and anticoagulants are common drugs used in treating seniors with mental disorder and potential drug interactions between them should be taken into account.
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