Abstract
Solar Urticaria (SU) is a rare, chronic inducible urticaria characterised by an itching or burning erythemal flare with or without whealing, that can develop within minutes of exposure to ultraviolet radiation (UVR) and/or visible light. It is hypothesised that an unidentified endogenous photo-allergen may be the trigger, leading to IgE-mediated mast cell degranulation. However, the evolution of the response and mechanisms involved are not well understood. We undertook a UVR provocation study with transcriptome analysis to examine early events in SU pathophysiology.
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