Abstract
Lipids synthesized on the skin are crucial to the antimicrobial barrier. Skin lipids also facilitate survival of lipophilic skin commensals in an otherwise dry and acidic ecological landscape. Skin-specific stearoyl-Coenzyme A desaturase 1 (SCD1) knockout mice are known to have dry, inflamed skin, with sebocyte atrophy and decreased synthesis of monounsaturated fatty acids, triglycerides, and wax diesters. Characterizing the skin microbiota in SCD1 knockout mice may facilitate better understanding of skin diseases in which alterations in lipids and the microbiota co-exist.
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