52-OR

Abstract

Objectives InterPregGen is investigating the genetic basis of pre-eclampsia in women from Europe, Central Asia and South America. Recruitment of 4000 women affected by pre-eclampsia, their partners and babies, and 4000 pregnant control women is on-going in Kazakhstan and Uzbekistan. The objective is Assessment of clinical features of pre-eclampsia in Central Asia. Methods The ISSHP definition of pre-eclampsia was used to identify women with new onset hypertension and proteinuria at 7 maternity units in Kazakhstan and 9 units in Uzbekistan. Pregnant controls had no history of hypertension in pregnancy. 1021 white European women recruited to the UK GOPEC genetic study of pre-eclampsia were used for comparison. Results Data were available from 1716 Kazakh and 897 Uzbek cases. 54% of Kazakh women with pre-eclampsia were primiparous, compared with over 70% of Uzbek and UK recruits. Factors predisposing to pre-eclampsia included high BMI ( P P 20% had a past history of hypertensive pregnancy. SBP and DBP at first antenatal visit were higher in cases than controls in Kazakh ( P Conclusions Interim analysis confirms common risk factors for pre-eclampsia in Central Asian women, and highlights areas of concern regarding outcomes for babies and mothers which merit further enquiry. Disclosure N. Zakhidova: None.