Abstract
Aberrant expression of the pyridoxal 5'-phosphate (PLP)-dependent enzymes: cystathionine- β-synthase (CBS) and cystathionine-γ-lyase (CSE), is generally observed in oncological contexts. Our group has recently recognized MALAT-1 as a pioneer lncRNA that modulates STAT-3-regulated hydrogen sulfide (H2S) production via CSE in breast cancer (BC), thereby nominating MALAT-1/STAT-3/CSE as a novel pathway that regulates H2S levels. Additionally, we elucidated the importance of dual suppression of MALAT-1 and CSE in BC to by-pass the compensatory feedback loop employed by CSE to restore H2S levels.
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