Abstract
Background: Radiotherapy enables good long-term local control and survival in early breast cancer patients. However, some patients experience acute or late adverse events that may decrease their quality of life. Cardiotoxicity of radiotherapy represents one of the important late adverse events. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is one of the biomarkers for the evaluation of suspected heart failure. Genetic factors can also contribute to the interindividual variability in the occurrence of adverse events. Because radiation leads to increased production of reactive oxygen species and oxidative stress, our aim was to evaluate the association of polymorphisms in antioxidant enzyme paraoxonase 1 (PON1) with NT-proBNP levels after radiotherapy, as a marker of cardiotoxicity in breast cancer patients.
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