Abstract
Skin hyperpigmentation is a biological process that results in an excess production of melanin. Tyrosinase inhibition is an effective approach to this condition, although inhibitors reported in the literature lack clinical efficacy or show toxic effects. Chalcone derivatives are well known tyrosinase inhibitors but insoluble in aqueous phase limiting its use in final product formulations. The aim of this study is to develop a new chalcone-related molecule that is safe and effective as a skin depigmenting and antiaging agent.
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