Abstract
Moreover mice receiving either wild type or Smad7 transgenic CD4+CD25cells developed colitis, but this was more severe in the latter. Analysis of inflammatory cytokines in the colon of mice revealed high IFN-gamma and low IL-17 in mice reconstituted with Smad7tg CD4+CD25T cells. Conclusions: High Smad7 makes T cells resistant to the CD4+CD25+T cell-mediated immunesuppression thereby worsening T cell-dependent intestinal inflammation.
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