Abstract
Over expression of math1 has been demonstrated to induce generation of hair cells in the cochlea in neonatal tissue culture models of the organ of Corti and math 1 generation of hair cells has recently been shown in vivo. We have examined an in vitro organtypic culture model as well as unilateral acute and bilateral chronic models of aminoglycoside vestibular injury. Delivery of Math1 using an adenovector (Ad) resulted in the generation of hair cells in adult mouse utriclular and saccular cultures. Mice treated acutely or chronically with aminoglycosides showed recovery of a significant portion of the vestibular neuroepithelium after AdMath1.11D was infused into the inner ear. Interestingly there was no recovery of hair cells noted within the cochlea in these mouse models and no hair cells noted outside of the vestibular neuroepithelium. Assessment of animals 2 months after vector infusion demonstrated a recovery of swim times compared to non-vector treated controls, demonstrating recovery of vestibular function after Math1 gene delivery.
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