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Abstract
We have reported that babies born small developed cardiovascular risks in middle ages in women. In the same cohort, this study was conducted to examine whether body shape at six years old (y.o.) has a relationship to cardiovascular risks in middle ages. Data were examined retrospectively for 721 women aged 41-69 years old who have received a medical examination at a single institution from 2007 to 2008. We collected the data of medical examination and a questionnaire body shape (thin, medium, fat) at six y.o. The relationship with birthweight and body shape at six y.o. was analyzed. Among those who were born small (< 2500g), 80, 16, and 4% became thin, medium, or fat, respectively, at six y.o. Body shape at six y.o. had a negative relation to future triglyceride, fasting glucose, HbA1C, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) levels, and positive relationship to high density lipoprotein cholesterol (HDL-C) level. Body shape at 6 y.o. had a negative relationship to cardiovascular risks in middle-aged women. Insulin and MOMA-IR levels had a negative relationship to body shape at 6.y.o., and development from low birthweight infant to childhood obesity was rare in this cohort.
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