516 CURCUMIN (DIFERULOYLMETHANE) BLOCKS Il-1β STIMULATED GLYCOSAMINOGLYCAN AND PROSTAGLANDIN E 2 RELEASE FROM CARTILAGE EXPLANTS IN AN IN VITRO MODEL OF OSTEOARTHRITIS

Abstract

KAM=0.12 and 0.05%Nm/BW.HT respectively). Function did not improve significantly following quadriceps strengthening in either alignment group but there was a significant improvement in knee pain in the more neutral group only (P< 0.001). Conclusions: Quadriceps strengthening did not have any significant effect on the KAM in participants with either more varus or more neutral alignment. The benefits of quadriceps strengthening on pain were more evident in those with more neutral alignment. Knee alignment thus represents a local mechanical factor that can mediate symptomatic outcome from exercise interventions in knee OA.