Abstract
Dysgerminomas account for 1% of all ovarian cancers and 50% of all ovarian germcell malignancies. Half of the pts can be cured with local treatment. Eighteen pts with advanced D were entered in this study. Age 27 (range 13–48) yrs. Seventeen had prior surgery, one prior radiotherapy (RT). Delay since initial diagnosis was median II weeks. PS 12:0, 3:1, 3:2. Three had only a local recurrence; all others also metastatic disease. Treatment consisted of P 20 mg/m2 d 1–5, V 0.15 mg/kg d 1,2, B 30 mg d 2,9 and 16 q 3 wks. Twelve pts obtained a CR (66%), five a PR (27%) and one could not be evaluated since immediate RT followed the CT. Of 18 pts 14 are alive and well, four died: 2 of progressive disease, 2 toxic death (one of septicaemia in leucopenia and one of lung fibrosis). Eighteen pts had 4 cycles, one 3, one 5 and one 6. Toxicity was as usual fur this regimen: gr 3–4 leucopenia 78%, thrombocytopenia 17%, N&V 33% and alopecia. Conclusion PVB is a very active regimen in adv. D. with an overall RR of 93% and a 77% rel. free survival after 3+ yrs.
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