Abstract

Melanogenesis is the interest of intense research since many decades. Regulation of this process is controlled by interactions with keratinocytes and fibroblasts in a paracrine fashion via soluble factors but also by exosomes. Exosomes are extracellular vesicles with an endosomal origin. Their role remains unclear but they were described as potential regulators of intercellular communication. Exosome-dependent messages are mostly constituted of microRNAs which regulate over a thousand of genes. Exosomal communication between keratinocytes and melanocytes was reported but exosomal communication between fibroblasts and melanocytes is poorly documented so we studied the impact of UV exposed fibroblasts on melanocytes and melanogenesis via the exosomal communication.

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