514 EFFICACY OF THE CONSUMPTION OF YOGURT SUPPLEMENTED WITH A NATURAL EXTRACT CONTAINING HYALURONIC ACID (MOBILEE™) IN ADULTS WITH MILDLY JOINT DISCOMFORT - A PROSPECTIVE RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED TRIAL

Abstract

Purpose: The objective of the present study was to determine the efficacy of the oral administration of yogurts supplemented with an extract rich in hylauronic acid in healthy individuals with mildly joint discomfort. Methods: A prospective doubled-blind randomized placebocontrolled trial with 40 healthy individuals with joint discomfort (VAS <4) was designed. The effect of oral supplementation with a natural extract rich in hyaluronic acid (MobileeTM) included in a yogurt matrix was evaluated on functional and quality of live parameters. The isokinetic Biodex system 3 for measuring maximal muscle strength, total work and power mean was used. Participants were divided into two groups (n=20) who consumed daily a yogurt supplemented with the extract or not supplemented during a period of 90 days. Results: The increase of the maximum peak torque of the knee extensors respect basal value was 7.6±7.6 Nm for the supplemented and 2.5±4.7 Nm for the control group at 180°/s (P=0.0582) and 6.5±5.8 Nm for the supplemented and -1.0±7.1 Nm for the control group at 240°/s (P<0.05). The same pattern of response was observed for total work with increases of 39.8±14.0 J for the supplemented and 2.1±11.9 J for the control group at 240°/s (P=0.0588) and for the power mean with increases of 16.6±6.1 W for the supplemented and -1.3±5.2 W for the control group at 240°/s (P<0.05). Differences were less pronounced for the knee flexors. No differences were detected for Lequesne score and SF-36 except for social functioning subscale at one month follow-up. Conclusions: This controlled prospective nutritional trial confirmed that 3 months oral consumption of a natural extract containing hylauronic acid (MobileeTM) in healthy individuals with joint discomfort of the knee provide improvements in muscular strength.