Abstract
Segmental vitiligo is a unilateral subtype of vitiligo characterized by a cutaneous depigmentation due to melanocyte loss from the epidermis and hair follicle reservoirs. In many cases, this skin depigmentation shares several clinical features and dysfunctions with herpes zoster (HZ). Thus, we searched sign of viral infection and presence of VZV in skin samples from 40 SV, 3 HZ and 10 generalized vitiligo. We observed that nuclear fusion in epidermal cells were statistically associated with recent SV whereas syncytia formation was associated with long-lasting SV.
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