Abstract

NBI was developed primarily to emphasize the mucosal microvasculature and to identify vascular alterations indicative of dysplasia. In different studies, the sensitivity and positive predictive value for the detection of high grade dysplasia (HGD) using mucosal and vascular abnormalities in patients with Barrett's esophagus (BE) has been between 86-100%. There is limited data published on the significance of NBI negative examinations in patients with BE and subsequent progression of disease if any. The aim of this study was to determine the prevalence of HGD and intramucosal cancer (IMC) in patients who are NBI negative as well as to determine progression of disease in this subset of patients.

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