Abstract
Photoprotection is a major issue in public health to prevent the harmful effects of sunlight radiations. Recently, we developed a new sunfilter called Phenylene Bis-Diphenyltriazine (or TriAsorB) that was recently approved in Europe (CAS N°55514-22-2). We combined TriAsorB in an innovative photoprotective system and we investigated by multiparametric approach the new SPF50+ suncare product photoprotection and maintenance in conditions of use, but also in real life extreme conditions. Photoprotection was assessed ex vivo by using human skin model exposed to solar-simulated radiation (SSR, UV+VIS light, 3 and 10 DEM) and quantification of sunburn cells as readout. Then, in vitro and in vivo approaches (55 adults, 44 children) were used to study the resistance of the sunscreen to high ultraviolet index, temperature, humidity but also water-resistance and use in tropical and sea/mountain environments. Perceived efficacy was also studied by 65 consumers. Sunburn analysis showed that the suncare prevented keratinocyte apoptosis under an acute SSR exposure (100% protection at 3DEM and 93.8% at 10DEM). Sun protection resistance evaluated in vitro performed in 4 different extreme conditions (continental, dry, polar, tropical) showed resistance > 75% to each condition (from 76.3% to 107.6%). Clinical studies confirmed the high performance (tolerance and efficacy) of this sunscreen under real sun exposure extreme conditions in tropical (i.e.: mean T° > 29°, mean humidity > 87% and mean UV index > 13). Indoor testing showed a very high resistance to water even after 6 baths of 20 minutes. The consumer test confirmed high satisfactory evaluations related to perceived efficacy and resistance (94% satisfied / mean score = 8,1/10) in extreme conditions. Altogether, the multiparametric approach demonstrated the high photoprotective performance of a new SPF50+ suncare product containing TriAsorB in different extreme conditions, suggesting it might be used in various climatic environment by consumers.
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