Abstract
HiC proximity-based sequencing have revealed that genomes are organized into megabase-sized topological associating domains (TADs) as units for cis-regulatory interactions. We have used systematic mapping of >650 human simple two-way balanced constitutional chromosomal rearrangements (BCRs) from both affected and heathy carriers to establish a first morbid map of this 3D-genome organization. Only ∼15% of the morbidity of BCRs can be explained by direct truncation of a known or plausible AD disease gene.
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