51. A study of clinical profile of patients with portal vein thrombosis

Abstract

Background and Aims: Portal vein thrombosis generally refers to a complete or partial obstruction of portal venous blood flow due to presence of a thrombus in the lumen of the vein or due to malignant obstruction of portal vein. Correct management by adopting adequate diagnostic and therapeutic measures is paramount. Hence this study was done with the aim to study the incidence, prevalence, aetiology of PV thrombosis patients and correlation with the severity of liver disease. Methods: We conducted a observational cross sectional study of patients of PV thrombosis in Outpatient department as well as hospitalized patients in the Medical gastroenterology of our hospital (n = 56). All patients with PV thrombosis on USG abdomen/PV Doppler/ CT abdomen were identified. BAVENO VI classification (2015) was used to classify patients with cirrhotic PVT. Results: Among the 56 patients we had, 43 (76.8%) were males and 13 (23.2%) were females. Acute/Recent presentation was in 6/56 patients. Cirrhosis (n = 46), Hepatocellular carcinoma (n = 4) were major liver related causes. Acute severe pancreatitis (n = 6) was major non-liver causes. Among patients with cirrhosis major causes were alcohol (n = 35), Hep B (n = 8), Hep C (n = 3). Mean MELD score was 17. One patient presented as ACLF. Majority of cirrhotic patients were in CPS B (82.6%) and CPS A (10.9%). Majority of PV thrombosis were in portal vein main trunk (Type 1) and were non occlusive. Conclusions: The occurrence of PV thrombosis correlates with the severity of liver disease with the incidence being high in patients with cirrhosis. Patients awaiting liver transplantation need to be treated in selected cases. The authors have none to declare.