Abstract
Monosodium urate (MSU) crystal is known to play an important role in the pathogenesis of gouty arthritis. Recently MSU has been proposed to be one of the potent IL-1 stimulators from adherent mononuclear cells (MNC). We intend to clarify the role of IL-1 in the pathogenesis of gouty arthritis. Adherent MNCs obtained from peripheral blood of gouty patient and cloned synovial cells were exposed to either MSU, Hydroxyapatite (HA), or calcium pyrophosphate dihydrate (CPPD). Cloned synovial cells were biopsied from patients with gout or osteoarthritis under arthroscopy and classified into three types, i.e. dendritic cells (DC) macrophage-like cells (MC), and fibroblast-like cells (FC). IL-1 production increased with a stimulation by crystals in a dose-dependent fashion when MNCs and synovial adherent cells were used. IL-1 activity was also detected in the culture-supernatants of three types of cloned synovial cells stimulated with any of the crystals tested. These results suggested that IL-1 may be an important mediator of crystal induced arthritis. This is the first report of IL-1 release upon stimulation of cloned synovial cells witn crystals.
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