Abstract
Although GTD is uncommon, it is extremely important because of the high degree of curability with adapted treatment. It is becoming important to preserve young patients (pts) fertility. We reviewed the productive history ofall pts who received chemotherapy (CT) for a GTD at ISA, between January 1982 and December 1993. Only 34 pts had subsequent pregnancies: 19 had molar pregnancies (MP) and 15 choriocarcinomas (CC). The mean age was 27 years (range 17–38). Pts with CC received a combined regimen of CT with Vincristin and Methotrexate 9 pts and Etoposide and Actinomycin 6 pts. All those with MP were treated by a CT associating (Methotrexate and Vincristin). All of them entered a complete remission, 7 after a salvage CT. MP n = 15 CC n = 19 Number of pregnancies 28 29 Normal term pregnancies 18 23 Spontaneous abortion 3 1 Ectopic pregnancy 0 1 Placenta Acreta 0 0 Premature birth 1 1 Congenital malformations 3 3 Conclusion It is actually important to achieve 2 objectives in treating pts with GTD: first to cure them, second to preserve their fertility.
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