Abstract
Inflammation plays a major role in different pathological and physiological conditions. Ultraviolet B radiation (UVB) is known to trigger the generation and release of multiple cytokines in the keratinocyte, which play a role in UVB-mediated pathology. Previously, we and others reported that UVB + other agents such as IL-1 or the lipid mediator Platelet-activating Factor (PAF) results in the synergistic production of cytokines such as TNFa. Subcellular microvesicle particles (MVP) which are released from cells in response to cellular stress have been implicated in multiple pathologic processes through their abilities to carry bioactive agents such as cytokines.
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