501: PREVALENCE OF CHRONIC DISEASES AND SUBSTANCE ABUSE ASSOCIATED WITH ORGANIC SLEEP DISORDERS

Abstract

Introduction: Some studies show there is a higher prevalence of chronic diseases and substance abuse associated with organic sleep disorders (OSDs). We aimed to identify the prevalence of chronic diseases and substance abuse. We also identified factors associated with higher odds of OSDs. Methods: The US population based retrospective study was performed using NIS database (2016-2018). Adults with OSDs, chronic diseases and substance use disorders were identified using the ICD-10-CM codes. Weighted univariate analysis was performed using a chi-square test to evaluate prevalence (primary+secondary diagnosis). The mix-effect survey logistic regression analysis was performed to identify chronic diseases and substance use disorders and their association with OSDs. Results: We found 87,761,798 hospitalizations, out of which 2,128,329 (2.43%) had organic sleep disorders (OSDs). Amongst spectrum of OSDs, prevalence of insomnia was 2.32%, REM sleep behavior disorder (0.1%), parasomnia (0.1%), circadian rhythm (0.1%), hypersomnia (0.04%), narcolepsy (0.06%). Population with OSDs was older (60 vs 58-years old) and OSDs were more common in age group 50-75 years (2.8% vs >75 years: 2.38% vs 18-50 years: 1.98%), male (2.53% vs female: 2.35%), and White race (2.74% vs Native American: 2.06% vs Black: 1.83% vs Hispanics: 1.69%). Concurrent prevalence of hypertension (61.48% vs 55.58%), obesity (17.00% vs 15.77%), drug abuse (13.80% vs 6.70%), alcohol abuse (10.50% vs 5.81%), tobacco abuse (22.57% vs 16.10%) and AIDS (10.79% vs 6.03%) was higher amongst OSDs in comparison without OSDs. (p<.0001) In regression analysis, we found patients with hypertension (aOR 1.18, 95% CI 1.17-1.19), dyslipidemia (aOR 1.27, 95%CI 1.26-1.28), obesity (aOR 1.09, 95%CI 1.08-1.10), AIDS (aOR 1.88, 95%CI 1.86-1.90), alcohol abuse (aOR 6.39, 95%CI 4.57-8.91), MI (aOR 0.65, 95%CI 0.64-0.66), angina pectoris (aOR 1.05, 95%CI 0.98-1.13), AIS (aOR 0.65, 95%CI 0.63-0.66), and TIA (aOR 0.79, 95%CI 0.75-0.82). Conclusions: In the nationwide representation, we have identified a higher prevalence and association of chronic diseases and drug and alcohol abuse with OSDs. More prospective studies are required for validation, early identification of population at risk, and risk mitigation to reduce the burden of OSDs.