501-P: Urinary C-Peptide Creatinine Ratio: A New Marker of Insulin Resistance and Diabetic Kidney Disease

Abstract

Introduction: Urinary C-peptide creatinine ratio (UCPCR) is used to access β cell function, but rare study had explored UCPCR in conditions with insulin resistance (IR). Some studies indicated the positive correlation between diabetic kidney disease (DKD) and IR. This study aims to explore the correlation among UCPCR,IR and DKD. Methods: Chinese hospitalized patients with type 2 diabetes were included (n=1299). Fasting UCPCR was collected in the morning. We divided patients into three groups by the tertile of UCPCR, the characteristics of three groups were compared. Results: In patients with the highest tertile of UCPCR, they had the lowest percentage of male (223 [51.6%] vs.294 [68.1%] vs. 302 [70.1%], P<0.001), highest homoeostasis model assessment 2 estimates of insulin resistance (HOMA2-IR) (2.0 [1.5,2.6] vs. 1.6 [1.2,2.2] vs. 1.5 [1.0,2.0], P<0.001), urinary albumin creatinine ratio (9.58 [4.67,36.42] vs. 7.14 [4.10,22.43] vs. 6.87 [3.60,22.94]mg/g, P=0.003) level,highest percentage of diabetic kidney disease (DKD) (121 [27.9%] vs. 95 [21.9%] vs. 98 [22.7%], P=0.078), coronary heart disease (CHD) (75 [17.4%] vs. 61 [14.1%] vs. 36 [8.4%], P<0.001) and stroke (77 [17.8%] vs. 55 [12.7%] vs. 46 [10.7%], P=0.007). After the adjustment for sex, age, duration, SBP, DBP, BMI, UA,TG, LDL-c, HbA1c, the history of smoke, hypertension and hyperlipidemia, UCPCR level had a positive correlation with the risk of DKD (OR=1.207,95%CI [1.026,1.419], P=0.023) and CHD (OR=1.302, 95%CI [1.069,1.587], P=0.009). Conclusions: UCPCR is a practical and non-invasive marker of insulin resistance and associated with increased risk of DKD and CHD. Disclosure Y. Wang: None. X. Cai: None. L. Ji: None.