Abstract
The results of hematological and biosynthetic studies in 15 subjects carriers of Hb Lepore and in 5 double heterozygotes for Hb Lepore and thalassemia are presented.In the carriers the hematological and biosynthetic data are compared with carriers of thal., while the five double heterozygous patients were compared with ° and + thal. major subjects. In the carriers of Hb Lepore no synthesis of chains was observed in the peripheral blood cells, on the contrary we found a peak in the bone marrow. Double heterozygous subject with circulating nucleated red cells showed in the peripheral blood chains synthesis.
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