5-year changes of retinal vascular diameters in elderly population in Beijing

Objective To investigate the relationship between high-sensitivity C-reactive protein (hsCRP) and retinal vascular diameter. Methods This study was a cross-sectional study, the population was from the Kailuan study (clinical trial research registration NO.: ChiCTR-TNC-1100 1489) in 2012—2013 (age≥40 years). All the people was checked by cardiovascular and epidemiological examination, of which 3 447 people had an analytical results of fundus color photography.The retinal vascular diameter was analyzed by software.Take the value of hsCRP 1% to 99% points and 3 363 people were finally included in the statistical analysis.The mean age of 3 363 people (male 1 880, female 1 483) was 56.69±10.10 years old.The correlation between hsCRP and central retinal artery equivalent(CRAE), central retinal vein equivalent (CRVE), arteriovenous ratio(AVR) were evaluated by Spearman correlation coefficient.Multivariate linear regression analysis was used to futher analyze the association between hsCRP and retinal fundus diameter parameters. Results The median value of hsCRP was 1.10(0.50, 2.21)mmo/L, CRAE was (174.16±24.36)μm, CRVE was (282.70±26.32)μm, AVR was 0.62±0.09.Spearman correlation analysis showed that hsCRP was positively correlated with CRVE (r=0.052, P=0.003) and negatively correlated with AVR (r=-0.052, P=0.002). The non-normal variables hsCRP were transformed into continuous variables lghsCRP, and CRAE, CRVE and AVR were used for multivariate linear regression analysis.After a number of factors were gradually corrected, the results showed that association between lghsCRP and CRVE (β=3.428) or AVR (β=-0.006) was statistically significant (P<0.05). LghsCRP was a risk factor for CRVE both in men and women after the calculation of gender stratification. Conclusions CRVE increased and AVR decreased with the increase of hsCRP.The changes of retinal vascular diameter may be associated with hsCRP as a marker to predict cardiovascular and cerebrovascular disease. Key words: Central retinal artery equivalent; Central retinal vein equivalent; High-sensitivity C-reactive protein

To describe the incidence trends and to access the histological changing patterns of thyroid cancer in urban areas of Beijing. Total of 4883 new cases diagnosed as thyroid cancer in 1995-2010 in urban areas of Beijing were extracted from the population-based data base of Beijing cancer registry, among which 1185 were males and 3698 were females with a coverage population of 56 143 454 person-years and 54 430 655 person-years, respectively. Incidence, age adjusted incidence, annual percentage change (APC) and gender specific incidence change of different histology patterns during last 16 years were calculate. There were 4883 cases diagnosed as thyroid cancer during 1995 - 2010 with the sex ratio of 1:3 (1185 males and 3698 females). Incidence rate of thyroid cancer in urban areas of Beijing increased dramatically from 1.55/100 000 (97/6 245 016) in 1995 to 9.90/100 000 (768/7 758 759) in 2010 with an increase rate of 538.71%. After adjusted by world population, the standardized incidence rate increased from 1.27/100 000 in 1995 to 6.96/100 000 in 2010 with a 12.12% annual percentage change (APC = 12.12%, P < 0.05). Among males, incidence rate increased from 0.85/100 000 (27/3 185 669) to 4.58/100 000 (179/3 912 458) with an increase rate of 438.82%. After adjusted by world population, the standardized incidence rate of males increased from 0.68/100 000 in 1995 to 3.19/100 000 in 2010 with an 11.09% annual percentage change (APC = 11.09%, P < 0.05). Among females, the incidence rate increased from 2.29/100 000 (70/3 059 347) to 15.31/100 000 (589/3 846 301) with an increase rate of 568.56%. After adjusted by world population, the standardized incidence rate of females increased from 1.89/100 000 in 1995 to 10.82/100 000 in 2010 with a 12.48% annual percentage change (APC = 12.48%, P < 0.05). Incidence rate ranked 18th and 12th in 1995 among males and females, respectively; while it ranked 14th and 5th in 2010 respectively. Among 4883 cases, 4594 cases were confirmed histologically as primary tumor accounting for 94.08% of total cases. Papillary carcinoma was the most common subtype accounting for 77.31% (3775/4883) of total cases. Among all the pathological types of thyroid cancer, the proportion of papillary carcinoma has risen from 51.55% (50/97) in 1995 to 87.63% (673/768) in 2010. However, the proportion of the follicular carcinoma decreased from 5.15% (5/97) to 1.69% (13/768). Incidence of thyroid cancer in urban areas of Beijing keeps increasing which is mainly due to the rising of papillary carcinoma. Risk factors of papillary thyroid cancer should be focused on when strategies for thyroid cancer prevention and control are conducted.

Objective: To investigate the relationship between six lipoprotein ratios and retinal vascular diameter. Methods: This cross-sectional study was performed from January 2010 to December 2010 and included 4 882 Chinese government officials age ≥40 years in Guangzhou who had no history of major cardiovascular events such as stroke or myocardial infarction. Serum lipids were analyzed and retinal vascular caliber was assessed using standard fundus photographs and validated software. A multiple linear regression model was designed to analyze the relationship between the following conditions: low density lipoprotein cholesterol/high density lipoprotein cholesterol (LDL/HDL), apolipoprotein B/high density lipoprotein cholesterol (ApoB/HDL), apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1), total cholesterol/high density lipoprotein cholesterol (TC/HDL), triglyceride/high density lipoprotein cholesterol (TG/HDL), low density lipoprotein cholesterol/apolipoprotein B (LDL/ApoB) ratios and retinal vascular diameter. Results: After adjustment for traditional cardiovascular risk factors, multiple linear regression analysis showed that LDL/HDL, ApoB/HDL, and ApoB/ApoA1 ratios all have a negative correlation with retinal arterial caliber ( β=-0.61, -1.91, -2.58, P=0.046, 0.020, 0.010 respectively). However, they have a positive correlation with retinal venous caliber ( β=2.01, 4.63, 5.99, respectively, P < 0.001). The relationships between TC/HDL, TG/HDL, and LDL/ApoB and retinal vascular caliber were not statistically significant. Conclusions: LDL/HDL, ApoB/HDL, and ApoB/ApoA1 ratios are significantly associated with a decrease in the retinal vascular caliber. The ratios of TC/HDL, TG/HDL, and LDL/ApoB are not associated with retinal vascular caliber. Key words: lipoprotein ratios; retinal vascular caliber; coronary heart disease; stroke; diabetes mellitus

To analyze the clinical presentations, and explore the diagnosis, and differential diagnosis of combined hamartomas of the retina and retinal pigment epithelium (CHRRPE). A retrospective review of five patients with suspected CHRRPE presented to Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, from Nov 2001 to July 2008. The clinical presentations, fundus characteristics, fundus fluorescein angiography (FFA), optic coherence tomography (OCT), as well as B ultrasound scan examinations were analyzed. The five patients were all male, ranging in age from 6 to 18 years (mean 12 years). The lesion was unilateral; there were not any associated diseases. Presenting symptoms included painless decrease in vision, metamorphopsia, and discovery of strabismus. Initial visual acuity ranged from 20/333 to 20/50. Locations of the lesion included on optic disk and adjacent retina, and in the macular area. Clinical characteristics were slight elevation on optic disk or in retina, different degree of hyperpigmentation, retinal vascular tortuosity, as well as epiretinal membrane formation. In arterial phase of FFA, there was hypofluorescence of choroid background, retinal vascular was tortuous and telangiectatic, and there was leakage from vessels within the lesion in venous phase and late phase. OCT showed obscuration of the normal retinal layers, elevated lesion with high reflectivity of the inner retina, and hyporeflective shadowing of the underlying tissue. B ultrasound scan showed slightly elevated solid mass involving the disc or adjacent retina in some patients. CHRRPE may be confused with other masses of the retina and choroid. Diagnosis of CHRRPE mainly depends on fundus manifestations, FFA and OCT. B ultrasound scan is useful for differential diagnosis.

Objective To describe the manifestations of ocular fundus secondary to systemic lupus erythematosus (SLE) . Methods This was a retrospective study. Thirty-six patients (57 eyes) who were diagnosed with SLE by the Department of Rheumatology in Peking Union Medical College Hospital during the years of 2002-2013 were enrolled in the study. These case studies from the Department of Ophthalmology were summarized. The patients included 4 males and 32 females from 14 to 71 years of age with a mean age of 32.6±11.5 years. Ocular anterior segments were examined with a slit lamp microscope. Fundus examinations were performed with papillary dilation, fundus photography and fundus fluorescein angiography. Results Twenty-four eyes showed retinal vasculitis. Eighteen eyes showed precapillary arteriole occlusion. Seventeen eyes presented with retinal vascular occlusion, 10 of presented with retinal artery occlusion, 5 presented with retinal vein occlusion, and 2 presented with retinal artery occlusion and vein occlusion. Six eyes presented with optic neuropathy, including 1 eye with neuropapillitis, 4 eyes with retrobulbar neuritis, and 1 eye with ischemic optic neuropathy. Three eyes presented with cytomegalovirus retinitis. Conclusion Retinal vasculitis, precapillary arteriole occlusion and retinal vascular occlusion are the most common manifestations of SLE as part of ocular fundus changes. Key words: Lupus erythematosus, systemic; Retinal vasculitis; Precapillary arteriole occlusion; Retinal artery occlusion; Retinal vein occlusion; Optic nerve diseases; Cytomegalovirus retinitis

The role of renin angiotensin system in retinal inflammation

Objective With a computer-assisted program,retinal vascular calibers were measured quantitatively.In this study the relationship between retinal vascular calibers and components of the metabolic syndrome was examined.Methods A total of 450 hypertensive patients were collected.Medical history,physical examination,blood tests,and retinal photographs were taken.Retinal vascular calibers were measured quantitatively from digital retinal photographs.In the hypertensive population the associations of retinal vascular calibers with components of the metabolic syndrome were described,and the factors that influenced retinal vascular calibers were analyzed.Results In the enrolled population,mean age was (57.53 ± 10.01) years,mean systolic blood pressure (138 ± 17) mm Hg(1 mm Hg =0.133 kPa),diastolic blood pressure (84 ± 10) mm Hg.Mean central retinal arteriolar equivalent(CRAE) was(129.26 ± 12.68) μm,and mean central retinal venular equivalent (CRVE) (198.25 ± 18.37) μm.After adjusting for age,gender,etc,CRAE in group with poor blood pressure control was smaller than that in the group with good blood pressure control [(126.45 ± 15.74) μm vs (130.30 ± 11.30) μm,P =0.029].CRAE tended to be narrower with worsened blood pressure control (P =0.075).CRVE was smaller in patients with normal high density lipoprotein-cholesterol (HDL-C) than in those with abnormal level [(197.36 ±17.62) μm vs (203.07 ± 21.52) μm,P =0.040].The diastolic blood pressure was raised along with the decreasing CRAE(P=0.009).And the HDL-C level was reduced as CRVE was increasing(P=0.042).Old age (r =-0.090,P=0.013) and poor blood pressure control(r=-0.098,P=0.038) were independent risk factors for narrow CRAE,while lowered HDL-C (r =0.105,P =0.024) and smoking (r =0.141,P =0.010) were independent risk factors for wide CRVE.Conclusions Narrow CRAE was related to poor blood pressure control,while wide CRVE was related to lowed HDL-C.Aging and poor blood pressure control were independent risk factors for narrow CRAE,while lowed HDL-C and smoking were independent risk factors for wide CRVE in the hypertensive patients. Key words: Retinal vascular caliber; Hypertension ; Diabetes mellitus; Dyslipidaemia

Objective To investigate the epidemiologic features of sarcopenia and its related indexes in elderly population in Beijing. Methods A cross-sectional study was conducted by interviewing the elderly population in Beijing with the standard questionnaire including demographic information, history of diseases, lifestyle, etc. Body muscle mass was measured by using a bioelectrical impedance analyzer (BIA). Physical function was evaluated bythe subjects′ 6-m gait speed (GS), and muscle strength was determined by handgrip strength (HS). Results Muscle mass declined with aging in the elderly (F=6.77, P=0.001), and the elderly had less muscle mass in the urban than in the rural (t=4.32, P=0.038). HS and GS significantly declined with aging(F=7.62 and 15.79, P=0.0005 and 0.000), especially in females and the rural elderly. Logistic regression showed that aging and female were associated with the high risk of HS decline (OR=1.13, 1.92, both P<0.05), while the urban elderly had lower risk of HS decline (OR=0.10, P<0.05). Aging, high body mass index, irregular lifestyle were positively related to GS decline(OR=1.12, 1.25 and 2.77 respectively, all P<0.05). The risk of GS decline was lower in the urban elderly having physical activity and hobbies (OR=0.08, 0.27 and 0.11 respectively, all P<0.05). Conclusions Sarcopenia-related indexes are significantly associated with aging and have population-specific difference. Positive and healthy lifestyle contributes to maintain muscle function in the elderly. Key words: The elderly; Sarcopenia; Muscle mass; Gait speed; Handgrip strength

Objective To explore the association of severity of disease and retinal vascular lesion staging with the level of serum C D 146 from different types of hypertensive disorders in pregnancy (HDIP) patients and normal pregnancy women.Methods One hundred and thirteen cases of women giving birth from January 2010 to January 2012 in Department of Gynecology and Obstetrics,Beijing Tongren Hospital,Capital Medical University were recruited,including 73 HDIP patients and 40 normal pregnant women.HDIP patients were divided into 3 groups according to the severity of disease:gestational hypertension group (n=22),mild preeclampsia group (n=23) and severe preeclampsia group (n=28).Normal pregnant women were used as normal pregnancy group (n=40).Prenatal and postnatal serum CD146 levels in 4 groups were detected by ELISA,and the correlation between CD146 levels and HDIP severity or retinal vascular lesion staging were analyzed.Results There were significant differences in serum CD146 levels of 4 groups prenatal and postnatal (all P＜0.05),and the CD146 levels increased with the severity of disease.CD 146 expression in preeclampsia of mild,severe group was significantly higher than that in normal pregnancy group and gestational hypertension group (all P＜0.05).The C D 146 levels in postnatal of 4 groups decreased as compared to those in prenatal (all P＜0.05).All the subjects were divided into 4 groups according to different stages of retinopathy,and there were significant differences in serum CD146 levels of 4 groups prenatal or postnatal (all P＜0.05),and the levels of serum CD146 increased with the severity of retinopathy.There were significant correlations between phases of retinal lesion and the severity of HDIP during prenatal and postnatal stage (prenatal:rx=0.793,P＜0.05; postnatal:rs=0.631,P＜0.05).Conclusion CD146 level may be used as an index reflecting the severity of HDIP and retinopathy. Key words: Hypertension, pregnancy-induced; Antigens, CD146; Pregnancy complications

To evaluate the fundus manifestation and treatment of Takayasu's arteritis. Retrospective case series was taken to study the clinical data of 15 patients (30 eyes) diagnosed with Takayasu's arteritis at Peking Union Medical College Hospital from 1992 to 2010. Examinations included visual acuity, slit-lamp, fundus, fundus fluorescein angiography (FFA), large vascular ultrasound, digital subtraction angiography (DSA), erythrocyte sedimentation rate (ESR) and reactive protein C (CRP). All patients were given systemic corticosteroids, immunosuppressive agents and anticoagulants. Three patients (4 eyes) received retinal photocoagulation, and 1 patient (1 eye) received vitrectomy combined with silicone oil tamponade. Fifteen cases aged 13 - 49 years [mean (33.6 ± 11.1) years] were enrolled, including 2 male and 13 female patients. Two patients recognized by initial presentation of impaired vision prior to the diagnosis of Takayasu's arteritis. Visual acuity: light perception -0.05, 6 eyes; 0.1 - 0.5, 4 eyes; 0.6 - 1.0, 5 eyes; and above 1.0, 15 eyes. The fundus examination revealed chronic ischemic retinopathy in 16 eyes characterized by microaneurysms, cotton-wool spots and peripapillary arteriovenous anastomosis, and complicated by vitreous hemorrhage, retinal detachment and proliferative retinopathy at the late stage. There was hypertensive retinopathy in 14 eyes with features of narrow retinal artery, arteriovenous crossing signs and retinal hemorrhage. FFA showed prolonged arm-to-retina circulation time and retinal circulation time, microaneurysms and neovasculature. Six cases were classified as brachiocephalic arteritis, and 9 patients belonged to extensive arteritis. ESR increased in 9 patients and CRP elevated in 5 patients. Capillary non-perfusion areas in 4 eyes subsided after retinal photocoagulation, and retina reattached in 1 eye after vitrectomy with visual acuity improved from light perception to count finger. Fundus manifestation of Takayasu's arteritis is usually characterized by chronic ischemic retinopathy and hypertensive retinopathy, and complications such as vitreous hemorrhage, retinal detachment and proliferative retinopathy occur at advanced stage. The first symptom in some patients can be impaired vision. The prognosis could be improved if ophthalmologists know fundus characteristics of Takayasu's arteritis and give timely and correct diagnosis and treatment.

Background Researches determined that the pathogenesis of retinal vein occlusion (RVO) is associated with primary open angle glaucoma (POAG) in Caucasian population.However, the relationship between RVO and POAG in Asian population is unclear. Objective This study was to survey the percentage of POAG in RVO patients in China. Methods A prospective cross-sectional observational study based on hospital was performed.Three hundred and seventy five patients with newly diagnosed RVO by fluorescein fundus angiography (FFA) were consecutively enrolled in Peking University Third Hospital from October 2011 to May 2013, and gonioscopy was carried out in all the patients.Glaucoma was diagnosed according to the criteria of the International Society of Geographical and Epidemiological Ophthalmology (ISGEO). RVO was classified into central retinal vein occlusion (CRVO), hemicentral retinal vein occlusion (HRVO) and branch retinal vein occlusion (BRVO) based on fundus photograph and FFA, or classified into arteriovenous crossing RVO (AV-RVO), optic cup RVO(OC-RVO), optic nerve RVO without optical nerve head swelling (NONHS-RVO) and RVO with optical nerve head swelling (ONHS-RVO) based on the sites of venous occlusion.The percentages of POAG in different types of RVO were calculated.This study was approved by Ethic Committee of Peking University Third Hospital, and written informed consent was obtained from each patient before entering study cohort. Results Three hundred and seventeen RVO patients finished screening of glaucoma, with the response rate 84.5%.The percentage of POAG is 8.2% in RVO patients, including 7.1% in the CRVO patients, 23.5% in HRVO patients and 6.2% in BRVO patients.The percentage of POAG was significantly higher in OC-RVO patients (27.9%) and NONHS-RVO patients (13.2%) than that in AV-RVO patients (4.7%) and ONHS-RVO patients (1.3%) (all at P<0.05). Conclusions The overall percentage of POAG in RVO patients in China is 3-4 times higher than general population.Higher percentage of POAG is found in OC-RVO patients and NONHS-RVO patients, suggesting that pathogenesis of RVO is probably associated with the glaucomatous anatomic changes of optical nerve head. Key words: Glaucoma/statistics & numerical data; Retinal vein; Thrombosis/statistics & numerical data; Glaucoma, open angle; Retinal vein occlusion; Humans

Objective: To assess the association between daily tea consumption and retinal vascular caliber in Chinese people. Methods: In this cross-sectional study, 4 430 subjects aged 40 years or older without a history of cardiovascular events were enrolled. Standard retinal photos and a validated computer-based program were used to measure retinal vascular caliber. A self-report questionnaire was administrated to obtain data regarding tea consumption and other socio-demographic information. Daily tea consumption was quantified into five dose categories (never, occasionally, 2 cups/day) and three common tea types (green, oolong and black/Pu'er tea, according to the degree of fermentation). Multivariate linear regression models were adopted to assess the cross-sectional association of tea consumption with retinal vascular caliber. Results: The age of the study participants was 58.8±9.9 years. Among them, 775 (17.49%) never consumed tea and, 645 (14.56%), 1 240 (27.99%) and 1 770 (39.95%) were accustomed to green, oolong and black/Pu'er tea, respectively. Retinal vascular calibers were not associated with doses of tea consumption after adjusting for lifestyle factors and other cardiovascular confounders, whether analyzed in all participants or in subpopulations accustomed to distinct tea types (all P>0.05). Conclusions: There is no significant association between daily tea consumption and retinal vascular caliber in a Chinese population. Key words: retinal vascular caliber; tea consumption; retinal microvasculature

To explore the relationship between female breast cancer incidence and the socioeconomic status in Beijing. The data of female breast cancer patients of Beijing residents diagnosed between 2001 and 2010 were sorted from the population-based surveillance database of Beijing Cancer Registry.28, 184 cases were included, covering 58, 427, 396 female person-years. Incidence rates, rates adjusted by world population in each year, mean and median age at diagnosis and the peak age group were calculated. JoinPoint software was applied to calculate the incidence trend and the annual percentage of changing (APC). Using the data from the Beijing Statistical Yearbook in 1991-2000, we calculated the gross output value of industry, the average wage of Beijing residents, the food expenditure level and the average wage in different districts in Beijing. The relationship between female breast cancer incidence, the average age (mean, median and the peak age groups) at diagnosis and the socioeconomic status in the last 10 years was also calculated. From 2001 to 2010, the incidence rate of female breast cancer in Beijing rose from 32.03/100 000 to 58.10/100 000, a total increase of 81.39% over the last 10 years and the annual percentage change was 5.76%, after adjusted by world population (APC = 5.76%, P < 0.05). The relationships between female breast cancer incidence from 2001-2010 and the gross output value of industry, the average wage of Beijing residents, the food expenditure level in 1991-2000 were significant (P < 0.05). The Pearson correlation coefficients were 0.928, 0.957, and 0.982, respectively. In terms of the data in different districts in Beijing, the relationships between the average age (mean, median and the peak age group) in 2001-2010 and the average wage of Beijing residence in 1991-2000 were also significant with a correlation coefficient of 0.806,0.785 and 0.754, respectively (P < 0.05). The increase of female breast cancer incidence rate in Beijing is positively correlated with the socioeconomic status, especially with the food expenditure level of Beijing residents over the last 10 years. The higher the economic development, the peak age of onset of female breast cancer is more postponed.

Background Choroidal neovascularization (CNV) is a major cause of visual loss in many fundus diseases.Fundus angiography (FA) is essential for the diagnosis, location and treatment of CNV.However, FA is an invasive examination method.Split spectrum amplitude decorrelation angiography (SSADA) OCT can quickly and clearly provide vascular signals.However, whether SSADA-OCT is feasible in the evaluation of CNV remains unclear. Objective This study was to detect and quantify CNV using OCT angiography. Methods Thirteen patients with unilateral CNV were included in Beijing Tongren Eye Center from June 2014 to August 2014.All affected eyes of the subjects were scanned with a high-speed frequency domain OCT.The SSADA-OCT images were obtained by scanning of macula covered 6 mm×6 mm area.The CNV area and grey scale were computed from the en face OCT images of retinal layer and choroidal layer.This study followed the Helsinki Declaration and was approved by the Ethics Committee of Beijing Tongren Hospital, and written informed consent was obtain from each patient prior to any medical examination. Results SSADA-OCT angiogram revealed CNV area and location confirmed by fluorescein angiography, and the CNV blood flow information of internal limiting membrane, inner plexiform layer, retinal pigment epithelium, and choroid was exhibited by OCT angiography.All CNVs with different causes showed the well defined and hyperreflected signal in macular region.The average CNV area was (0.15±0.09)mm2, and the average grey scale of CNV was 75.40±32.35 in the affected eyes, and that in the contralateral eyes was 26.99±22.87 in the 300 μm area, showing significant elevation in gray scale in the affected eyes compared with the contralateral eyes (t=6.946, P<0.001). Conclusions OCT angiography is a noninvasive observation technique of retinal and choroidal blood flow.It can provide quantitative information and detailed images of CNV. Key words: Tomography, optical coherence/methods; Choroidal neovascularization/diagnosis; Fluorescein angiography; Split-spectrum amplitude-decorrelation angiography; Retina; Macula

It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.