Abstract
A theory is proposed that 5-thio-D-glucose successfully prevents spermatogenesis in mice by interfering with the sugar metabolism of testicular cells. The sulfur analog of D-glucose presumably acts in 2 ways: 1) some of the thio-sugar competitively inhibits the active transport of D-glucose across cellular membranes and 2) some of the thio-sugar enters the cell and becomes phosphorylated resulting in a mono phosphate which is an inhibitor of phosphoglucomutase an enzyme of the glycolytic pathway. At doses of about 33 mg/kg in mice 5-thio-D-glucose resulted in atrophy of the testes and in complete inhibition of spermatogenesis. The effects were found to be totally reversible after treatment with the thio-sugar ended. No reduction in libido and no pathological changes in the testes occurred.
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