Abstract
The present review briefly outlines main methods for the synthesis of 5′-norcarbocyclic nucleoside analogs and the biological activity spectrum of these compounds. Antiviral, antitumor, antibacterial, and anti-inflammatory properties of 5′-norcarbocyclic nucleoside analogs are described. Cellular enzymes, such as S-adenosylhomocysteine hydrolase, telomerase, adenosine kinase, and inosine monophosphate dehydrogenase, as well as HIV reverse transcriptase, are considered as target enzymes.
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